I’ve always loved creative activities like knitting and baking. These activities help me relax after a long day, and they’re often easy enough to complete that I can do them while listening to my favorite playlist or watching one of my favorite movies. While some […]
Month: December 2018
The ideal post-exercise meal is a combination of healthy carbs and protein. What you eat and drink after your workout—and when—can have a big impact on your next performance. What do you eat first after a workout? Most athletes pay fairly good attention to what […]
Young children who had infections were more likely to develop mental disorders such as schizophrenia, eating disorders, and autistic spectrum disorder in subsequent years, according to a nationwide study in Denmark.
Among more than 1 million Danish children, those who had been hospitalized for severe infection had an 84% increased risk of being diagnosed with a mental disorder before age 18 (HR 1.84, 95% CI 1.69-1.99) and a 42% increased risk of filling a psychotropic medication prescription (HR 1.42, 95% CI 1.37-1.46), reported Ole Köhler-Forsberg, MD, of Aarhus University Hospital in Risskov, Denmark, and colleagues.
Those who had received medication such as antibiotics for their infections also had a higher risk of developing a mental disorder (HR 1.40, 95% CI 1.29-1.51) and of filling a psychotropic prescription (HRR 1.22, 95% CI 1.18-1.26), Köhler-Forsberg and colleagues wrote in JAMA Psychiatry.
The relationship was a dose-response association, with children who had more infections and more severe infections having a higher risk of developing a mental disorder. The risk was also highest between 0 to 3 months after the infection, researchers found.
“This does not mean that infections do lead to a mental disorder, but the bigger take-home message is that there is an intimate relationship between the body and the brain,” Köhler-Forsberg told MedPage Today. “In some way, infections, or their effect on the immune system, do have an effect on the brain.”
In an accompanying editorial, Vivian Labrie, PhD, and Lena Brundin, MD, PhD, both of the Van Andel Research Institute in Grand Rapids, Michigan, wrote that the study was “compelling” and “strongly supports” the assumption that severe infection and the use of anti-infective agents may result in the onset of mental illness.
Brundin told MedPage Today that previous studies have demonstrated that the downstream effects of inflammation caused by infection could have profound effects on the brain. Immune cells and cytokines passing the blood-brain barrier could create an inflammatory response, which has been linked with psychiatric symptoms such as depression, she said. The association could also be attributed to certain infections in a more direct way, for example, when the parasite Toxoplasma gondii integrates itself into brain cells and disrupts the production of dopamine.
She added that it is also possible that the antibiotics were behind this association, rather than the infections themselves. However, she emphasized that each of these explanations are speculative and need to be validated by further research.
“It hasn’t really been shown before that the increased risk happens quickly after infection,” Brundin told MedPage Today. “There’s really strong support that there is a mechanistic relationship and that there is something about those infections that is triggering these illnesses.”
In the editorial, Brundin and Labrie noted that patients in the study might be more likely to be diagnosed with a mental health disorder due to the frequency with which they met with their providers. They also noted that the psychological stress of being hospitalized could bring out certain anxiety disorders in children, but concluded that neither of these explanations appear likely, the former because only certain disorders exhibited altered risks, and the latter because the association persisted with the use of anti-infective agents as well as hospitalizations.
For their part, Köhler-Forsberg and colleagues pointed out that frequent medication use “may be a proxy” for a stressful environment including social deprivation and parental anxiety, among other possible residual confounders.
Data for the study came from Denmark’s national health registries, covering hospitalizations, prescriptions, and mental health diagnoses. Some 1.1 million children born from Jan. 1, 1995 to June 30, 2012 were included and were followed until death, emigration, or end of the study period (June 30, 2013).
In total, 42,462 individuals were hospitalized for a mental disorder during the study period (66.4% male, average age 9.5 at diagnosis), and 56,847 individuals redeemed a prescription for psychotropic medication (60.1% male, average age 6.3 at prescription).
Mental health risk was particularly increased for schizophrenia spectrum disorders, obsessive-compulsive disorder, personality and behavior disorders, mental retardation, autism spectrum disorder, attention deficit-hyperactivity disorder, oppositional defiant disorder and conduct disorder, and tic disorders. Antibiotics were associated with the greatest risk increase (HR 1.22, 95% CI 1.17-1.27), whereas antivirals and antimycotics did not increase the risk estimates.
In a sensitivity analysis of 821,346 siblings, the association persisted — children hospitalized for infection also showed increased risk for hospitalization for a mental disorder (HR 1.21, 95% CI 1.16-1.27), and treatment with psychotropic medication (HR 1.17, 95% CI 1.14-1.19), compared to siblings not treated for infection, researchers report. Children who were prescribed anti-infective agents were also more likely to be hospitalized for any mental disorder compared to siblings without severe infection history (HR 1.16, 95% CI 1.07-1.26). But, there was no increased risk for receiving psychotropic medication (HR 0.97, 95% CI 0.93-1.01) compared with siblings not experiencing severe infection.
Köhler-Forsberg and her team reported that their study was limited because the maximum follow-up time for each individual was 18 years, and researchers did not include disorders treated through means other than prescription medications. Additionally, antibiotics were often overprescribed, they wrote, and some anti-infective agents in this study may have been prescribed for viral infections.
This study was funded by grants from The Lundbeck Foundation and the Independent Research Fund Denmark.
Brundin received funding from the Michael J. Fox Foundation, Veterans Affairs, and National Institutes of Health, and Labrie received grants from the Department of Defense and the Alzheimer’s Society of Canada.
No other disclosures were reported.
The fitness industry, even today, is filled with myths and claims that are outright misinformed and misleading. These myths circulate quite easily and thus, make people believe in the baseless claims and follow them quite easily. In this piece, we will bust some of the […]
Breaking News Emails Get breaking news alerts and special reports. The news and stories that matter, delivered weekday mornings. Dec. 7, 2018 / 9:46 PM GMT By Shamard Charles, M.D. A report this week about a Seattle woman who died from a brain-eating amoeba after […]
A woman used a neti pot with filtered tap water and later died from a brain-eating amoeba.
A woman who was told by her doctor to rinse her sinuses twice daily to clear up a chronic sinus infection died from a brain-eating amoeba.
The woman, 69 from Seattle, was using tap water filtered using a Brita Water Purifier in a neti pot, according to a report published in the peer-reviewed International Journal of Infectious Diseases. The Centers for Disease Control and Prevention recommends that only distilled, sterile or cooled boiled water be used for sinus irrigation.
After a month of clearing her sinuses with the non-sterile water, a quarter-sized red rash appeared on the right side of her nose. Her doctor told her it was rosacea and prescribed an ointment, according to the report. The rash didn’t clear and she saw a dermatologist several times seeking answers, but biopsies didn’t result in any definitive diagnosis.
A year after the rash developed, the woman had a seizure. At that time, a CT scan showed a half-inch lesion on her brain. Doctors performed surgery to remove the mass, which they say had “unusual characteristics.” A specimen was sent to Johns Hopkins University for analysis.
Days later, her left arm and leg became numb and she had an “altered mental status.” A consulting neuropathologist from Johns Hopkins suggested there might be an amoebic infection and later a drug for such infection was given to the patient. However, her condition didn’t improve and her family ultimately decided to take her off life support.
Tests after death showed the woman died of Balamuthia mandrillaris, an amoeba that lives in soil and the Centers for Disease Control and Prevention also say it’s possible it lives in water. Balamuthia can travel to the brain and can cause a deadly infection. Little is known about how people contract the amoeba and how to prevent it.
She tested negative for Naegleria fowleri, another amoeba able to cause deadly brain infections that was linked to a death of a Louisiana man who used a neti pot in 2013.
The Seattle article authors warn that because cases such as this one are so difficult to diagnose, “it is possible that many more cases of Balamuthia have been missed.”
Around the world, more than 200 cases of Balamuthia infection have been diagnosed with at least 70 cases in the U.S., according to the CDC.
Follow Ashley May on Twitter: @AshleyMayTweets
Roelly Winklaar Looks Absolutely Huge In Off-Season Training Session – Fitness Volt Bodybuilding & Fitness News
There are few people who deserve an Olympia title and there’s no debate Roelly Winklaar is one those people. Wow!!… That’s what anyone would say (Or think) when looking at Roelly Winklaar in his current off-season shape. He placed third in 2018 at the Mr. […]
The mom of a 6-year-old boy who developed a flesh-eating bacteria is warning other parents to take their child’s injuries seriously. Melissa Evans, from Pike County in Mississippi, said her son Chance Wade mentioned pain in his leg, but they waited three days before taking […]
When Gritty, the new mascot of the Philadelphia Flyers hockey team, made his debut on September 24, the internet reacted with horror that quickly turned to delight. The googly-eyed mascot filled a void the internet didn’t know it had, and he was quickly memefied, deified, and Jimmy Fallon-ified. Mental Floss even wished him luck in a list about short-lived mascots. We love Gritty.
Despite her devotion to the New York Rangers, Mental Floss’s editor in chief Erin McCarthy is as obsessed with Gritty as the rest of the world, frequently posting his latest antics to Slack. On November 9, she was thinking about Gritty and also Carvel ice cream cakes when something occurred to her. Take Carvel’s Cookie Puss, remove the nose, add a gaping mouth, make it orange, and BAM, it’s Gritty. So, naturally, she tweeted about it:
— Carvel Ice Cream (@CarvelIceCream) November 10, 2018
And then, Carvel began tweeting to Erin about the Gritty cake again.
We have a surprise…
What do you think…we see a resemblance pic.twitter.com/cIuyHMrSLm
Start with a classic Cookie Puss cake base …
You can see a video of the cake being made here:
To our delight, Carvel sent the cake to the Mental Floss offices, where we devoured it—but not before taking a few detail shots, which we now present for your enjoyment:
Gritty Ice Cream Cake tastes exactly how you’d expect—like chaos and sugar and the color orange, like if Fudgy the Whale met the void. Gritty Ice Cream Cake tastes incredible.
So how does our editor-in-chief feel about this whole situation?
Editor’s note: Jenn Wood did not get to partake in the deliciousness of this Gritty ice cream cake party, and is currently not speaking to her co-workers as a result.
In one popular episode of SpongeBob SquarePants titled “Band Geeks,” Squidward and the Bikini Bottom gang perform a rousing rendition of David Glen Eisley’s song “Sweet Victory” at the fictional Bubble Bowl. Now, in the wake of the death of SpongeBob creator Stephen Hillenburg, fans of the cartoon sponge are pushing for the song to be played at the Super Bowl, according to ComicBook.com.
A Change.org petition to have the song performed during the Super Bowl’s halftime show has been signed by more than 575,000 people—more than halfway to their goal of getting 1 million signatures. It was created in memory of Hillenburg, who died last week at the age of 57 due to complications from ALS, ak.a. Lou Gehrig’s disease.
“As a tribute to his legacy, his contributions to a generation of children, and to truly showcase the greatness of this song, we call for ‘Sweet Victory’ to be performed at the halftime show,” the petition reads.
The petition’s creator, Isreal Colunga, of Portland, Oregon, wrote that the petition “started as a joke on Twitter” but turned into something much larger. “It’s beautiful and it shows how much SpongeBob and Mr. Hillenburg impacted our lives,” Colunga writes. Bob Kulick, the guitarist who performed ‘Sweet Victory’ alongside Eisley, even shared the petition on his Facebook page.
The NFL hasn’t responded to this particular request, but Maroon 5 is already slated to be one of the halftime performers. If the tribute to SpongeBob did somehow get the green light, it wouldn’t be the strangest show in Super Bowl history. When the San Francisco 49ers played the Cincinnati Bengals in 1989, a magician dressed as Elvis Presley (called Elvis Presto, of course) performed the “world’s largest card trick” in 3D as spectators in disposable glasses watched on.
Christian radio host Linda Harvey is very upset about a gay kiss on TV. The Macy’s Thanksgiving Day Parade on Thursday (November 22) featured a same-sex kiss during a performance from the stars of lesbian-themed Broadway musical The Prom, prompting a wave of reactions from viewers […]